i2k Retina™ is based on the most sophisticated technology in the world for automatically registering and aligning two-dimensional images and for automatically constructing montages. At the core of our technology, is the powerful i2Align™ image registration algorithm, which both decides whether or not two images overlap and computes the inter-image transformation (pixel location mapping function) between them. Hence it is both a registration and recognition algorithm. In i2k Retina version 2.0, this is combined with a new algorithm to compute the topological arrangement of all the images, even when there are ambiguities in the image set. Once the arrangement is decided upon, i2k Retina computes the transformations that combine all the images, mapping them into a common "aligned" coordinate system, by employing an "unbiased" estimation technique that produces accurately-aligned images with minimal geometric distortion despite low inter-image overlaps.

In order to produce accurately-aligned and seamlessly-montaged images, much more is needed than just i2Align™ and our topological arrangement algorithm.. DualAlign™ has developed a host of supporting technologies that work together to make the i2k Retina™ software powerful, widely-applicable, and easy to use. These technologies, illustrated below, include automatic masking, single and multi-image illumintation correction, camera parameter estimation, inter-image seam selection and final composite blending. They are used in different combinations for different choices of tools and image types to produce the results. For montaging color fundus images, the full suite of tools is applied, while for aligning fluorescein angiograms, only the automatic masking and the core i2Align™ algorithm are needed. Users of i2k Retina™ may also experiment with aligning and montaging other types of images, including microscrographs. In this case, montaging and seam selection will be applied, but no camera modeling and no illumination correction are used.