i2k Retina, based on DualAlign's i2Align image registration and recognition algorithm, is the most sophisticated software package in the world for automatically aligning and montaging retinal images. i2k Retina can create wide field-of-view montages of color fundus images, allowing users to see much of the retina in a single, seamless display. It can align fluorescein images to provide a stable view of the retina over the stages of circulatory filling, and it can be used to combine color fundus images with fluorescein images, relating the surface appearance to the blood flow images. Users have even applied i2k Retina to montaging microscopy sequences of the layers of the rat retina!

The i2Align algorithm underyling i2k Retina is faster and smarter than the Dual-Bootstrap (GDB-ICP) algorithm our team developed while at Rensselaer Polytechnic Institute. Using this algorithm, i2k Retina can register almost any set of retinal images, finding the common structures in the images and ignoring the differences. If you can see common structures, i2k Retina will find them and register the images.

We welcome you to download i2k Retina and join the following list of prestigious institutions that have declared that i2k Retina is the best software for montaging and registering of images they have ever used.

• Moorfields Eye Hospital
• Wilmer Eye Institute, John Hopkins University
• Wisconsin Medical Center
• University of Wisconsin, Madison
• University of California at Berkley
• University of Houston, College of Optometry

Downloading and installing i2k Retina presents users with several different ways to exploit the power of the technology:

• A simple-to-use UI allows users to run the software, align and montage images, and preview the results. For many users, particularly those who want to just "see" the aligned and montaged images, this will be enough. Checking an image montage is one clear example, but anyone who wants to combine modalities or observe a stabilized time series of images will find the "preview" capabilities quite powerful.
  
• A command-line executable allows users more control over the software and provides the ability to align or montage multiple image sets at once. Use of the executable is explained in detail in getting_started.pdf.
• A library and header file are provided, with a C-level interface, for users who would like to incorporate i2k Retina into their own applications. The location of the header files and library for both Windows and Macs is explained in getting_started.pdf.
• In addition to the image output from i2k Retina, users can output the transformation functions that map the images on top of each other and output the inter-image correspondences that our technology uses to drive the registration process. This output may be obtained through the UI, through the command-line executable and through options set in the library function calls. The transformations and the output correspondenses are explained in xforms-and-matches.pdf.

Two different software packages are available, with i2k Retina each available on both Windows (XP and Vista) and Mac (OS X 10.4 and 10.5). i2k Retina is DualAlign's most complete and most powerful software system, including specialized algorithms for retinal image montaging and sequences.